Custom TALENs Services
Negotiable Min Order Quantity Unit
- Required Quantity
-
- Place of Origin
- U.S.A
- Brand name
- Creative Animodel
- Payment Terms
- Negotiable
- Production method
- Negotiable
- Shipping / Lead Time
- Negotiable / Negotiable
- Category
- Pharmaceutical Intermediates
Creative Animodel
- Verified Certificate
-
10
| Product name | Custom TALENs Services | Certification | - |
|---|---|---|---|
| Category | Pharmaceutical Intermediates | Ingredients | - |
| Keyword | talens gene editing , custom talens services , talens , talens design | Unit Size | - |
| Brand name | Creative Animodel | Unit Weigh | - |
| origin | U.S.A | Stock | - |
| Supply type | - | HS code | - |
Product Information
TALEs (Transcription Activator-Like Effectors) are proteins that bind to DNA in a sequence-specific way. By fusing such a TALE to a Nuclease (a "TALENs"), a highly specific DNA scissor is made. The TALENs technology has become a powerful approach for genome editing in a number of animal models.
In just over several years of operation, Creative Animodel has provide TALENs products and services for the generation and analysis of genetically modified rodent models. We have generated more than 50 custom models and provided services to clients at over 28 different institutions worldwide.
The key benefits of TALENs are:
- Easy and ready to use
- Fast and time-saving
- Effortless, trusted results
Our Services include：
Design of TALENs
We provide Custom TALENs design, synthesis, validation and support, to optimize success rates of all your gene editing projects.
You can combine every gene editing project specific Custom TALEN with the validation level of your choice!
Gene editing project specific TALEN
TALEN Basic: suitable for any gene editing project
TALEN Sure KO: designed to introduce frame shift mutations within the 1st coding exon of any gene
TALEN CpG: designed to overcome the impact of methylated DNA on TALEN nuclease activity
onstruction of TALENs
TALEN are constructed by ligating individual RVD repeat sequences together using a modified Golden Gate Cloning Protocol. The modification includes: Truncated and changed N-term and C-term sequences of the TALEN; Cloning strategy suitable for making individual or a library of TALENs; 5bp instead of 4bp sticky ends on the individual TALEN building blocks/repeats for better ligation efficiency.
B2B Trade
| Price (FOB) | Negotiable | transportation | - |
|---|---|---|---|
| MOQ | Negotiable | Leadtime | Negotiable |
| Payment Options | Negotiable | Shipping time | Negotiable |
- President
- Mr.Zhang
- Year Established
- 2005
- Company introduction
-
Creative Animodel totally understands that it is a challenging and long-time process to develop novel therapies especially anticancer regimens. As an experienced bioscience CRO, we would like to help you accelerate the process through our preclinical services including PD, PK, toxicology services and the establishment of tumor-bearing animal models, the supply of tumor cell lines and tissues, and the support of tumor related biotechniques.
Our highly experienced preclinical team has performed a huge number of PD, PK, and toxicology experiments to evaluate novel compounds. According to our detailed protocol, specific aspects of drug property and its mechanism of action are fully understood. During researches, the study results will be sent to clients in a timely and cost-effective manner. If necessary, clients can also work with our PD, PK or toxicology team to design the most appropriate protocol and monitor the whole experimental process.
In the past years, Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemoinduced models using these tumor samples and cell lines.
Additionally, Creative Animodel provides powerful tumor-related biotechniques support for clients. Our services focus on in vitro and in vivo preclinical studies as well as toxicological, pathological, and toxicokinetics researches.
Creative Animodel has constructed systematic data and experience in pharmacology or oncology services. If you are interested in our laboratory, please contact us. Our research scientists will work closely with you to develop detailed study protocols to meet your goals.
- Main Markets
-
Australia
Canada
Singapore
South Korea
U.S.A
- Main Product
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