Constitutive Knockout

Constitutive Knockout


Negotiable Min Order Quantity Unit

Required Quantity
Place of Origin
U.S.A
Payment Terms
Negotiable
Production method
Negotiable
Shipping / Lead Time
Negotiable / Negotiable
Keyword
conventional, subcloning, homologous, germline transmission
Category
Pharmaceutical Intermediates

Creative Animodel

Membership
BIZ
Country / Year Established
U.S.A U.S.A / 2005
Business type
Manufacturer
Verified Certificate

10

Product name Constitutive Knockout Certification -
Category Pharmaceutical Intermediates Ingredients -
Keyword conventional , subcloning , homologous , germline transmission Unit Size -
Brand name - Unit Weigh -
origin U.S.A Stock -
Supply type - HS code -

Product Information

Creative Animodel's high-throughput conventional knockout technology enables us to identify and validate the utility of genomic targets within a living model at an extraordinary scale and speed. With Creative Animodel, you get targeted knockouts generated through proven technologies and comprehensive phenotypic data analyzed across consistent protocols.

Steps

1 : Subcloning and characterization of the locus of interest
2 :Constitutive knockout vector construction (targeting vector)
3 :Homologous recombination in ES cells
4 :Blastocyst injection and chimera generation
5 :Breeding to the F1 and F2 generation

 

In the past 20 years, Creative Animodel has been focused on offering custom design and generation of knockout mice for research needs. Germline transmission has been achieved for all knockout projects with competitive timelines. 

 

 

B2B Trade

Price (FOB) Negotiable transportation -
MOQ Negotiable Leadtime Negotiable
Payment Options Negotiable Shipping time Negotiable

Creative Animodel

Country / Year Established
U.S.A U.S.A / 2005
Membership
BIZ
Business type
Manufacturer

10

President
Mr.Zhang
Year Established
2005
Company introduction

Creative Animodel totally understands that it is a challenging and long-time process to develop novel therapies especially anticancer regimens. As an experienced bioscience CRO, we would like to help you accelerate the process through our preclinical services including PD, PK, toxicology services and the establishment of tumor-bearing animal models, the supply of tumor cell lines and tissues, and the support of tumor related biotechniques.

Our highly experienced preclinical team has performed a huge number of PD, PK, and toxicology experiments to evaluate novel compounds. According to our detailed protocol, specific aspects of drug property and its mechanism of action are fully understood. During researches, the study results will be sent to clients in a timely and cost-effective manner. If necessary, clients can also work with our PD, PK or toxicology team to design the most appropriate protocol and monitor the whole experimental process.

In the past years, Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemoinduced models using these tumor samples and cell lines.

Additionally, Creative Animodel provides powerful tumor-related biotechniques support for clients. Our services focus on in vitro and in vivo preclinical studies as well as toxicological, pathological, and toxicokinetics researches.

Creative Animodel has constructed systematic data and experience in pharmacology or oncology services. If you are interested in our laboratory, please contact us. Our research scientists will work closely with you to develop detailed study protocols to meet your goals.
 

Main Markets

Australia Australia

Canada Canada

Singapore Singapore

South Korea South Korea

U.S.A U.S.A

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