Conditional Knockout
Negotiable Min Order Quantity Unit
- Required Quantity
-
- Place of Origin
- U.S.A
- Payment Terms
- Negotiable
- Production method
- Negotiable
- Shipping / Lead Time
- Negotiable / Negotiable
- Category
- Pharmaceutical Intermediates
Creative Animodel
- Verified Certificate
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10
Product name | Conditional Knockout | Certification | - |
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Category | Pharmaceutical Intermediates | Ingredients | - |
Keyword | conditional knockout mice , onditional knockout service , conditional knockout | Unit Size | - |
Brand name | - | Unit Weigh | - |
origin | U.S.A | Stock | - |
Supply type | - | HS code | - |
Product Information
Creative Animodel has developed an innovative platform "RSKOT" (rapid and stable knockout technology) enabling the generation of conditional knockout mouse lines starting from the same targeted ES cell clones. This reduces the risk associated with constitutive knockouts (lethality, complex phenotype etc.) by allowing the switch to conditional models if necessary. This approach avoids time delay and facilitates model up-grading.
- Tissue-specific. Conditional knockouts provide you temporal and tissue-specific gene knockout control while allowing the mouse model to mature under the normal operating role of your gene(s) of interest. The induced mutations cause a controlled inactivation of the targeted gene, providing a developed adult model without the function of your targeted gene.
- Inducible. Inducible mouse models allow for the inactivation of genes in specific cells and tissues at specific times. This strategy can bypass the limits that are usually observed with constitutive knockout models (e.g. embryonic lethality, compensatory mechanisms or complex phenotype). Creative Animodel has developed a few inducible expression systems, such as Tetracycline-Inducible Systems and Cre/lox System. In contrast with some tissue-specific knockouts, this strategy enables the study of gene inactivation at various defined developmental ages or stages. Inducible knockouts enable to more accurately model age-related diseases.
- 2-in-1 KO. Generating both constitutive and conditional KO models with the same gene would usually require work on two separate projects. At Creative Animodel, however, we have developed the "RSKO" technology that allows us to generate both constitutive and conditional KO mice from a single project. This innovative solution results in substantial savings in time and money.
As a world leader in gene targeting services and custom mouse model production, Creative Animodel has over a decade of experience serving clients across six continents. Our full-service model has enabled medical and academic researchers to receive over one thousand successful and unique gene targeted model lines. Furthermore, our solutions enable investigators to obtain reliable data early in the development cycle, reduce costs, accelerate time-to-market, and create a strong competitive advantage.
Our services provide clients with access to world class scientific staff who are knowledgeable in the unique and inherent difficulties of development and reproduction in knockout technique, and to specialized resources across the globe.
B2B Trade
Price (FOB) | Negotiable | transportation | - |
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MOQ | Negotiable | Leadtime | Negotiable |
Payment Options | Negotiable | Shipping time | Negotiable |
- President
- Mr.Zhang
- Year Established
- 2005
- Company introduction
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Creative Animodel totally understands that it is a challenging and long-time process to develop novel therapies especially anticancer regimens. As an experienced bioscience CRO, we would like to help you accelerate the process through our preclinical services including PD, PK, toxicology services and the establishment of tumor-bearing animal models, the supply of tumor cell lines and tissues, and the support of tumor related biotechniques.
Our highly experienced preclinical team has performed a huge number of PD, PK, and toxicology experiments to evaluate novel compounds. According to our detailed protocol, specific aspects of drug property and its mechanism of action are fully understood. During researches, the study results will be sent to clients in a timely and cost-effective manner. If necessary, clients can also work with our PD, PK or toxicology team to design the most appropriate protocol and monitor the whole experimental process.
In the past years, Creative Animodel has collected more than 80 cases of human tumors. At present, 30 cases are growing as subcutaneous xenografts in nude mice, and others were retained as nitrogen frozen samples. Tumors types comprise: stomach, lung, liver, pancreas, kidney, bladder, skin, breast, brain, colon, prostate, sarcomas (bone), uterus, ovary and hematological models. Also, we have a full range of human tumor cell lines that have been validated in our in vivo efficacy studies or reported in literature. According to the requirements from clients and our experience, Creative Animodel can offer subcutaneous, orthotopic, metastatic, transgenic and chemoinduced models using these tumor samples and cell lines.
Additionally, Creative Animodel provides powerful tumor-related biotechniques support for clients. Our services focus on in vitro and in vivo preclinical studies as well as toxicological, pathological, and toxicokinetics researches.
Creative Animodel has constructed systematic data and experience in pharmacology or oncology services. If you are interested in our laboratory, please contact us. Our research scientists will work closely with you to develop detailed study protocols to meet your goals.
- Main Markets
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Australia
Canada
Singapore
South Korea
U.S.A
- Main Product