Amiloxate
Amiloxate [USAN]
Isoamyl p-Methoxycinnamate
Product Name: Isoamyl p-Methoxycinnamate
Synonyms:4-Methoxycinnamic acid,isoamyl ester,ISOAMYL p-METHOXYCINNAMATE,AMILOXATE;ISOAMYL 2-(4-METHOXYPHENYL)-2-PROPENOATE;ISOPENTYL 4-ETHOXYCINNAMATE;3-(4-METHOXYPHENYL)-2-PROPENOIC ACID,ISOAMYL ESTER;2-PROPENOIC ACID,2-(4-METHOXYPHENYL)-,2-METHYLBUTYL ESTER;ISOAMYL ESTER 3-(4-METHOXYPHENYL)-2-PROPENOIC ACID;2-METHYLBUTYL ESTER 2-PROPENOIC ACID,2-(4-METHOXYPHENYL)-;2-(4-METHOXYPHENYL)-2-METHYLBUTYL ESTER 2-PROPENOIC ACID;2PROPENOIC ACID,3 (4METHOXYPHENYL),3METHYLBUTYL ESTER;ISOPENTYL P-METHOXYCINNAMATE;3-METHYLBUTYL 3-(4-METHOXYPHENYL)-2-PROPENOATE;Isopentenyl-4-methoxycinnamate;Isoamyl P-Methoxy-Cinnamate;
CAS No.: 71617-10-2
Molecular Formula C15H20O3
Molecular Weight 248.3175
CAS Registry Number 71617-10-2
EINECS 275-702-5
BRN 3132627
Density 1.031g/cm3
Refractive index 1.524
Purity: 98% min.
Packing: 25kg net/drum.
Brand: Nanjian

What is it?
Isoamyl p-Methoxycinnamate is an organic compound that absorbs ultraviolet (UV) light.

Safety Information
The European Commission’s Scientific Committee on Cosmetology (SCC) conducted a safety evaluation of Isoamyl p-Methoxycinnamate. Based on their review, they concluded that use of this ingredient in cosmetic products as a UV light absorber at a maximum concentration of 10% would not pose a health hazard.

Why is it used in cosmetics and personal care products?
In Europe, Isoamyl p-Methoxycinnamate is an approved UV filter, which means the ingredient can be added to sunscreen products that are designed to protect the skin from the sun. In Europe, sunscreen products are considered cosmetic products.
In the United States, sunscreen products are Over-the-Counter (OTC) drugs and only certain ingredients have been approved by the Food and Drug Administration (FDA) for use in these products. In assessing sunscreen active ingredients, the FDA reviews both safety and efficacy. The safety and efficacy of Isoamyl p-Methoxycinnamate has not yet been reviewed for sunscreen use by the FDA and it cannot be used in sunscreen drug products.
For cosmetics in the United States, Isoamyl p-Methoxycinnamate can be used as a UV light absorber. In this case, the ingredient serves to protect the product from deterioration by absorbing, reflecting, or scattering UV light.

Scientific facts:
Isoamyl p-Methoxycinnate, also referred to as Amiloxate, absorbs UV radiation which is an important cause of premature aging of the skin and in the development of melanoma and other forms of skin cancer.

[ Properties Computed from Structure]

Molecular Weight 248.3175 [g/mol]
Molecular Formula C15H20O3
XLogP 4
H-Bond Donor 0
H-Bond Acceptor 3
Rotatable Bond Count 7
Exact Mass 248.141245
MonoIsotopic Mass 248.141245
Topological Polar Surface Area 35.5
Heavy Atom Count 18
Formal Charge 0
Complexity 263
Isotope Atom Count 0
Defined Atom StereoCenter Count 0
Undefined Atom StereoCenter Count 0
Defined Bond StereoCenter Count 0
Undefined Bond StereoCenter Count 1
Covalently-Bonded Unit Count 1

[ Descriptors Computed from Structure]
IUPAC Name: 3-methylbutyl 3-(4-methoxyphenyl)prop-2-enoate
Canonical SMILES: CC(C)CCOC(=O)C=CC1=CC=C(C=C1)OC
InChI: InChI=1/C15H20O3/c1-12(2)10-11-18-15(16)9-6-13-4-7-14(17-3)8-5-13/h4-9,
12H,10-11H2,1-3H3