Anti-TDGF1 (clone huB3F6)-Disulfide-linker-DM4 ADC
Negotiable Min Order Quantity Unit
- Required Quantity
-
- Place of Origin
- U.S.A
- Payment Terms
- Negotiable
- Production method
- Negotiable
- Shipping / Lead Time
- Negotiable / Negotiable
- Category
- Medical Devices
Creative Biolabs
U.S.A
- Verified Certificate
-
9
| Product name | Anti-TDGF1 (clone huB3F6)-Disulfide-linker-DM4 ADC | Certification | - |
|---|---|---|---|
| Category | Medical Devices | Ingredients | - |
| Keyword | antibody , adc | Unit Size | - |
| Brand name | - | Unit Weigh | - |
| origin | U.S.A | Stock | - |
| Supply type | - | HS code | - |
Product Information
| This ADC product is comprised of an anti-TDGF1 monoclonal antibody (clone huB3F6) conjugated via a Disulfide-linker to a DM4.The DM4 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM4 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death. | Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released. | Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells. | Binds to tubulins, interrupts microtubule dynamics. |
B2B Trade
| Price (FOB) | Negotiable | transportation | - |
|---|---|---|---|
| MOQ | Negotiable | Leadtime | Negotiable |
| Payment Options | Negotiable | Shipping time | Negotiable |
- President
- Mr
- Address
- SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA
- Product Category
- Other Pharmaceutical Chemicals
- Year Established
- 2005
- Company introduction
-
Creative Biolabs is a leading company of recombinant antibody (rAb) discovery and manufacturing, providing high quality service to customers in academia and industry fields all over the world.Our cutting-edge hybridoma development and phage display platforms allow the production of the most comprehensive list of recombinant antibody products and extensive service portfolio at the most competitive price. Our products range from antibody / peptide libraries, Biosimilar cell lines, Chimeric antigen receptor (CAR) products, antibody-drug conjugates (ADCs) to engineered antibodies such as therapeutic antibodies, nanobodies, bispecific antibodies and intrabodies. We also provide professional custom antibody discovery and engineering services, featuring phage display library construction, antibody humanization, chimerization, engineered antibody production (Fab, scFc, tribody, bispecific antibody, nanobody, minibody, etc.), antibody labeling, hybridoma/stable cell line development, membrane protein production and cGMP-manufacturing which enable larger scale antibody production for development of animal-based assays and clinical trials.
- Main Product
_2.jpg "Recombinant Human Anti_Golimumab Antibody _Kd _ 2_8 nM__1")
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