Thymalin Bi Peptide, Thymalin

Thymalin Bi Peptide, Thymalin


Negotiable Min Order Quantity Unit

Required Quantity
Place of Origin
China
Payment Terms
Negotiable
Production method
Negotiable
Shipping / Lead Time
Negotiable / Negotiable
Keyword
thymalin bi peptide, thymalin
Category
Other Pharmaceutical Chemicals

Aierry Co.,ltd.

Membership
BIZ
Country / Year Established
China China / 2016
Business type
Manufacturer
Verified Certificate

8

Product name Thymalin Bi Peptide, Thymalin Certification -
Category Other Pharmaceutical Chemicals Ingredients -
Keyword thymalin bi peptide , thymalin Unit Size -
Brand name - Unit Weigh -
origin China Stock -
Supply type - HS code -

Product Information

 

AIAP0016 Thymalin Bi Peptide (Synthetic Thymalin)
Sequence: Pyr-L-Ala-L-Lys-L-Ser-L-Gln-Gly-Gly-L-Ser-L-Asn-OH

Thymalin Research

Thymalin is an immunomodulator polypeptide derived from the thymus. Synthetic Thymalin is a basic polypeptide made up of 38 amino acids residues. Studies have shown that this immunomodulator molecule does occur naturally in the thymus. A summary of studies and findings concerning the functions on the thymus are described below.

Thymus

It is a specialized bilobed secondary lymphoid organ which is critical to the development of functionally active and self-tolerant T-cells. It is also a component of the adaptive immune system. Studies have shown that the actions of the thymus are mediated by immunomodulators.

In the thymus, the precursor thymocytes do develop into mature T-cells. The process of maturation involves recombination and rearrangements of the gene segments that code for the T-cell receptor. This leads to the development of unique peptide: MHC (Major Histocompatibility Complex) combinations of the receptor and this mediates central tolerance. These T-cell receptors mediate antigen recognition and antigen presentation. The mediation is occurs through interactions between epitopes of an antigen and the corresponding paratopes of the T-cell receptor.

The process of gene rearrangements is prone to errors which could lead to the development of either non-functional T-cells or T-cells which react strongly to self-antigens (autoreactive T-cells). To prevent these errors from occurring, the developing T-cells undergo selection based on their T-cell receptors affinity and specificity. Functional T-cells undergo positive selection and the autoreactive T-cells undergo negative selection. This occurs in the central medulla of each lobe of the thymus.

The mature T-cells eventually enter into the general circulation where they constitute the T-cell repertoire which mediates the functions of the adaptive immune system. Normally, the normal T-lymphocyte population is achieved early in life and this leads to involution of the thymus in early adulthood. However, loss (or sometimes complete absence) of the thymus before these population thresholds are reached results in DiGeorge Syndrome which is characterized by severe immunodeficiency. There is still residual T-cell lymphopoiesis throughout the adult life. Nonetheless, studies have shown that complete involution of the thymus in old age is associated with increased susceptibility to severe infections and cancer development. This has been attributed to immune deficiency which impairs the immune response to infections and impairment of immune surveillance against tumors.

Other diseases associated with thymic dysfunction are allergic hypersensitivity, Severe Combined Immunodeficiency Syndrome (SCID), lymphomas, Myasthenia Gravis, thymomas and the rarity APECAD (Autoimmune PolyEndocrinopathy-Candidiasis-Ectodermal Dystrophy).

Thus, it is evident from the studies carried out on the thymus that the inductive environment provided by the thymus leads to the development of a functional, self-tolerant T-cell repertoire.

Thymic immunomodulators have the potential of restoring the integrity of thymic activity in a dysfunctional or diseased thymus, thus treating the associated immune deficiency or managing its severity. One of the most potent and efficacious pharmaceutical preparation of thymic immunomodulators is Thymalin.

How Thymalin works

It is based on the principle that natural peptides have a significantly high potential of restoring normal biologic activity and are also associated with an acceptable toxicological profile. Studies have shown conclusively that the biologic activity is restored by the active component of the drug (the polypeptide constituent) while the toxicological profile is usually associated with the vehicle used.

In Thymalin, the active component is a polypeptide, and the vehicle used is a combination of water-soluble salts. Studies have shown that the immunostimulant effects of Thymalin are due to the capability of the polypeptide to modulate the ratio of the subpopulations of functional immunocompenent cells.

 

B2B Trade

Price (FOB) Negotiable transportation -
MOQ Negotiable Leadtime Negotiable
Payment Options Negotiable Shipping time Negotiable

Aierry Co.,ltd.

Country / Year Established
China China / 2016
Membership
BIZ
Business type
Manufacturer

8

President
Peter Liang
Address
A201, No.1 Qianwan 1st road, Qianhai economic district, Shenzhen.
Product Category
Other Pharmaceutical Chemicals
Year Established
2016
No. of Total Employees
1-50
Company introduction

 

Aierry Co.,ltd is a professional supplier of peptide related products,
peptide costom R&D and costom manufacturing, our products
include generic peptide, bioactive peptide and cosmetic peptide.
Aierry is located in Shenzhen Qianhai Economic district. our peptides
are exported to North America, West Europe, South America,
East Europe and Southeast Asia etc. We insist on"Quality first,
Innovation, Credibility and Win-win", providingquality peptides
to our customers worldwide.

Vison: to be the leading provider of peptide products  
Mission:  provide high quality peptides  
Core Value:  Quality, Innovation, Credibility, Win-win
Main Markets

Argentina Argentina

Canada Canada

Egypt Egypt

Iran Iran

Iraq Iraq

Israel Israel

Jordan Jordan

Saudi Arabia Saudi Arabia

U.A.E. U.A.E.

U.S.A U.S.A

Main Product

Related Products

Other buyers also search

Membership Grade

BUYER

Biz Pro VIP

SELLER

Biz Pro VIP
팝업닫기
Live Chat A new message arrives
from a business partner.

No Data

  • There is no data to load
  • Check out the My TK > My Inquiries list.
  • After agreeing to the use of the Live Chat service, the list is printed only when there is at least one history of receiving or sending a Live Chat request.

If you have not yet agreed to use the Live Chat service,

You can use the Live Chat freely after agreeing to the use of the Live Chat service.

View more
View more