Hyperbaric oxygen therapy Oxygen is normally supplied by inhalation to our body. It combines with hemoglobin inside of the red corpuscle(Bonded oxygen) HBOT machine induces hyper pressure. It can increase the concentration of the melted oxygen in liquid(melted oxygen) The melted oxygen supplies directly to each cell. Adequate tissue perfusion and sufficient oxygen supply are two basic requirements for the healing responses of body. Without these the tissues enter a hypoxic state. Hypoxiz impairs many healing processes collagen synthesis, bacterial killing, angiogenesis, and epithelialization. Hypoxiz slows wound healing and favors bacterial growth. HBOT accelerates normal healing mechanisms. The increased concentration of oxygen dissolved in plasma reaches tissues with poor or compromised vascular supply(increased diffusion distance). Tissue oxygenation is also improved as the resultant vasoconstriction decreases edema(decreased intercapillary distance) HBOT stimulates the proliferation of fibroblasts and endothelial cells for at least three days post treatment. Oxygen is delivered to the tissues at levels that actually inhibit bacterial growth. Tissue oxygen tension has been shown to be the most important local factor affecting oxidative leucocyte killing. HBOT potentiates the growth and viability or many microorganisms while enhancing antibiotic effectiveness and the immune response of patient. HBOT has been widely used in human such as sports medicine, plastic surgery, and health industries.