Iron Dextran Injection

【Main Ingredient】Dextran and hydrogen ferric oxide compound

【Pharmacological Actions】This article through to the body directly added to improve due to lack of iron iron and cause anemia. Single dose toxicity to medicine in oral and intravenous dextran iron LD50 are larger than 2500 mg/kg. Age 6 to 8 weeks of MF1 porton mice and rats and sandy rat subcutaneous injection high doses of iron preparation (10 mg / 10 g), six weeks after in rats and mice liver found no iron in star shaped DouZhou cells aggregate phenomena, the liver also did not appear fibrosis phenomenon. Male C57BL / 10 mice intraperitoneal injection of single dose 12 mg dextran iron, nine weeks mouse liver lobules body appear no damage. More toxic dosage of medicine: to rats and rabbits total dose of 20 mg to/kg doses of the study found that more than iron, in low dose group had no significant damage appeared in the rat high dose group compared with the control, rats weight increased, liver enlargement appeared, but did not lead to liver damage. To age 10 months of dog Beagle 2 times per week is equivalent to 50 mg/kg each time the iron dextran iron, lasting five weeks, the results showed that the influence of the liver and other animals similar, but in sclera appear splash. To Spraque-dawley mice short-term give big dose dextran iron (100 mg/kg of iron 7 days), liver of animals to dissect histologic study, found in the liver cells appear in the iron deposition, but did not see the damage to the liver cells. Liver cells iron concentration significantly increased and liver cell lipid peroxide and poly (amino oxide and poly (amino oxidase activity increase relevant. No evidence that the product of the reproductive capacity have toxic effect, and the teratogenic mutations and the effect that can cause cancer.

【Pharmacokinetics】Dextran iron intravenous drip, can be meshy endodermis system cells absorb, especially in the liver and spleen. Iron can slowly release and integrated with protein. 6 to 8 weeks after can be observed to strengthen haematogenous function. Cycle of iron plasma half-life of 5 hours, total iron (a combination of and circular) half-life for 20 hours. After the injection in muscle, because of molecular dextran iron larger, from the injection site be absorbed into the capillaries and lymphatic again into the blood. So after the injection of blood concentration improve slowly, about 24 to 48 hours blood medicine concentration to peak. Circular iron was meshy endodermis system to gobble up cells, will break to iron and dextran. Iron can immediately and protein binding forming blood iron flavin or iron protein, and a small form transferrin. The iron in the physical adjustment can be added hemoglobin and consumption iron reserves. Muscle injected dextran iron, most of the 72 hours is absorbed, and most of the rest of the iron in the next three to four weeks is absorbed. Iron not easily cleared in from the body, excessive accumulation may have toxicity. This complex molecular larger (165000 Da), to through renal cleared. A small amount of iron may be through the urine and feces cleared. Dextran iron can be metabolism and eliminate.

【Indications】1.lactation period and the lamb, such as calves, piglets correspondent congenital and nutritional anemia, with both inosine, vitamin B12, vitamin C use effective prevention and treatment for benefit rigid, slow growth.

2.pregnancy and lactation yellow to increased and for iron intake of iron deficiency anemia caused by inadequate; Or lost too much or absorb barriers caused by the uncontrolled hemorrhagic acute and chronic anemia, parasites anemia, digestive function of aplastic anemia; Benefit can be enhance the capacity of resistance, prevent young yellow, diarrhea, added benefit the body trace element; On piglets, iron deficiency anemia effects;

3.can significantly increase the body physique, increase weight, improving group survival rate;

4.with red filaments aid in the treatment of disease.

【Application and Dosage】Deep extensor muscles injection: born piglets 1 ~ 3 days, 1 ml/head; Born seven to 14 days, 2 ml/head. Jiang pig 3 ml/head; Calves born within 3 days 3 ml/head, the lamb was born three days 2 ml/head, avoid excessive use.

【Adverse Reaction】Injection agent to the poisoning excess iron, which should be paid attention to control the doses

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[Company Introduction]

Hangzhou Huadi Group Co.,ltd is built in 2011, including five branch companies. They are HangzhouHuajin Pharmaceutical Co.,ltd (built in 2002), Zhejiang Huajin Yike Pharmaceutical Co.,ltd (built in 2004),Zhejiang Huaercheng Bio-Pharmaceutical Co.,ltd, Hangzhou Huajin Yunshang Pharmaceutical Co.,ltd(built in 2010) and Hangzhou Mixi Bio-Technology Co.,ltd.

We nearly have twenty years experience in researching, developing and manufacturing pharmaceutical raw material, intermediate and medicine(mainly bio-extract), all of them meet the standard of GMP. Part of ourproducts are also wildly used in food, health food and cosmetics, they are high safe, high efficient, and areexported to all over the world.