Veenat (Imatinib Capsules)

Veenat 100 (Imatinib) is used for chronic myelogenous leukemia (CML), GIST (gastrointestinal stromal tumors) and other cancers. It works by blocking the abnormal protein needed for the cancer to spread. In patients with CML, the presence of a chromosome referred to as the Philadelphia chromosome can affect the blood cells, causing them to synthesize an abnormal protein (Bcr-Abl tyrosine kinsase).The active compound contained in this drug is known as a tyrosine kinase inhibitor. A key step in its mechanism of action when used for CML is the ability to inhibit the bcr-abl tyrosine kinase from triggering the phosphorylation of proteins, which is required for the cancer cells to develop. This in turn causes the destruction of the cancerous cells, allowing for the treatment of symptoms. It is generally used in cases when bone marrow transplants are not considered as the primary treatment option. Gastrointestinal stromal tumors are treated because of the medicine`s ability to inhibit the mutant PDGFRA or KIT gene, which causes the death of abnormal cells. Other indications include acute lymphoblastic leukemia, myelodysplastic syndrome, myeloproliferative disorders, chronic eosinophilic leukemia, hypereosinophilic syndrome, DFSP (dermatofibrosarcoma protuberans) as well as other disorders that have not been referenced here.

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