Chlorogenic acid

Properties

Molecular formula: C16H18O9

Molar mass: 354.31 g/mol

Density: 1.28 g/cm3

Melting point: 207 - 209 °C

Usage: antibiosis, antiviral, anti-inflammatory

antimutagenicity, anti-aging, anti-tumor, depressurization

Another name: chlorogenic acid,, Caffeic acid

CAS.No.: 327-97-9

Chlorogenic acid   Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean. The ester of caffeic acid with quinic acid, is one of the most abundant polyphenols in the human diet with coffee, fruits and vegetables as its major sources. Its antioxidant and anticarcinogenic properties have been well established in animal studies

Chemical properties

Structurally, chlorogenic acid (CGA) is the ester formed between caffeic acid and (L)-quinic aicd(1L-1(OH),3,4/5-tetrahydroxycyclohexanecarboxylic acid). Isomerisation  of the  quinic acid in position 3, (3-CQA), 4 (4-CQA) and 5 (5-CQA). Isomerisation at position 1 has not yet been reported. Isomers of chlorogenic acid are found in potatoes. They are 4-O-caffeoylquinic acid (crypto-chlorogenic acid), 5-O-caffeoylquinic acid(neo-chlorogenic acid), 3,4-dicaffeoylquinic acid and 3,5-dicaffeoylquinic acid

biological  properties

The biological properties of chlorogenic acid depend on its absorption in the gut and on its metabolism. Although the bioavailabilities of caffeic and ferulic acids have been investigated in several studies  little is known about the bioavailability of chlorogenic acid. In rats and humans, chlorogenic acid ingested as a pure compound or in coffee has not been detected or found only as traces in urine. This was attributed to a poor absorption of chlorogenic acid through the small intestine barrier. Chlorogenic acid was also shown to be metabolized by the gut microflora into various aromatic acid metabolites including m-coumaric acid and derivatives of phenylpropionic and benzoic acids. These microbial metabolites may contribute to explaining the biological properties of polyphenols poorly absorbed in the gut such as chlorogenic acid. However, their importance has seldom been assessed in vivo

Biological importance
This acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters; Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease .Chlorogenic acid has been proven in animal studies in vitro to inhibit the hydrolysis of the glucose-6-phosphate enzyme in an irreversible fashion. The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of glycogen.Chlorogenic acid can be used as anti-infectious active ingredient, it has wide anti-virus, anti-bacteria effects, and has relatively lower toxicity and side-effects. It has obvious anti-infectious effects, and does not like to lead Anti-microbial Resistance.

Chlorogenic Acid, Best ingredients for cosmetic products

I. Strong Anti-oxidant ability

II.100% water soluble

III.Very stable at normal temperature

IV.Pure white

V. No hypersusceptibility

VI.100% natural

VII.100% safe for Honeysuckle Flower is drink as a tea for more than 2000 years in China.